Seung-Il Choi Selected Research

Hereditary Corneal Dystrophies

1/2020	Lysosomal dysfunction of corneal fibroblasts underlies the pathogenesis of Granular Corneal Dystrophy Type 2 and can be rescued by TFEB.
10/2017	Melatonin reduces endoplasmic reticulum stress and corneal dystrophy-associated TGFBIp through activation of endoplasmic reticulum-associated protein degradation.
3/2016	TGF-β regulates TGFBIp expression in corneal fibroblasts via miR-21, miR-181a, and Smad signaling.
11/2015	Histone methylation levels correlate with TGFBIp and extracellular matrix gene expression in normal and granular corneal dystrophy type 2 corneal fibroblasts.
8/2015	Inhibitory Effect of Tranilast on Transforming Growth Factor-Beta-Induced Protein in Granular Corneal Dystrophy Type 2 Corneal Fibroblasts.
1/2015	Lysosomal trafficking of TGFBIp via caveolae-mediated endocytosis.
8/2011	Altered mitochondrial function in type 2 granular corneal dystrophy.
5/2011	Inhibition of TGFBIp expression by lithium: implications for TGFBI-linked corneal dystrophy therapy.
4/2010	Involvement of TGF-{beta} receptor- and integrin-mediated signaling pathways in the pathogenesis of granular corneal dystrophy II.
7/2009	Corneal dystrophy-associated R124H mutation disrupts TGFBI interaction with Periostin and causes mislocalization to the lysosome.

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Seung-Il Choi Research Topics

Disease

13	Corneal dystrophy Avellino type 01/2021 - 07/2009
10	Hereditary Corneal Dystrophies 01/2020 - 07/2009
2	Neuroblastoma 01/2008 - 02/2004
2	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2005 - 02/2004
1	Alzheimer Disease (Alzheimer's Disease) 01/2019
1	Neoplasm Metastasis (Metastasis) 02/2016
1	Colonic Neoplasms (Colon Cancer) 02/2016
1	Neoplasms (Cancer) 02/2016
1	Retinal Vein Occlusion 12/2015
1	Macular Edema 12/2015
1	Corneal Opacity 08/2015
1	Scrapie 02/2005
1	Mitochondrial Diseases (Mitochondrial Disease) 02/2005
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 11/2002

Drug/Important Bio-Agent (IBA)

10	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2021 - 08/2011
9	Proteins (Proteins, Gene)FDA Link 01/2019 - 02/2004
3	MelatoninIBA 10/2017 - 01/2008
2	Amyloid (Amyloid Fibrils)IBA 01/2019 - 02/2004
2	betaIG-H3 protein (keratoepithelin)IBA 03/2016 - 08/2015
2	LithiumIBA 02/2016 - 05/2011
2	Transforming Growth Factor beta (TGF-beta)IBA 08/2015 - 07/2009
1	Protein Isoforms (Isoforms)IBA 01/2019
1	Biomarkers (Surrogate Marker)IBA 01/2019
1	A-factor (Streptomyces)IBA 10/2017
1	MicroRNAs (MicroRNA)IBA 03/2016
1	4-phenylbutyric acid (Buphenyl)FDA Link 01/2016
1	Bevacizumab (Avastin)FDA Link 12/2015
1	Histones (Histone)IBA 11/2015
1	tranilastIBA 08/2015
1	Proteasome Endopeptidase Complex (Proteasome)IBA 08/2014
1	UbiquitinIBA 08/2014
1	AntioxidantsIBA 08/2011
1	Melatonin Receptors (Melatonin Receptor)IBA 08/2011
1	IntegrinsIBA 04/2010
1	Complementary DNA (cDNA)IBA 04/2010
1	Transforming Growth Factor beta Receptors (TGF beta Receptors)IBA 04/2010
1	PeriostinIBA 07/2009
1	Penicillamine (Cuprimine)FDA Link 01/2008
1	Free RadicalsIBA 02/2005
1	LipidsIBA 02/2005
1	Tyrosine (L-Tyrosine)FDA Link 02/2005
1	phospholipase D1IBA 02/2005
1	Phospholipids (Phosphatides)FDA LinkGeneric 02/2005
1	1-dodecylpyridoxal (PLD)IBA 02/2005
1	EnzymesIBA 02/2005
1	Peptides (Polypeptides)IBA 02/2004
1	Biological ProductsIBA 11/2002
1	Prion ProteinsIBA 11/2002
1	CalciumIBA 11/2002

Therapy/Procedure

3	Therapeutics 11/2015 - 05/2011
1	Injections 12/2015